Publications Cellular Analysis

Jadhav, V., Hackl, M., Klanert, G., Hernandez Bort, J.A., Kunert, R., Borth, N., Grillari, J. (2014) Stable overexpression of miR-17 enhances recombinant protein production of CHO cells. J Biotechn 175, 38-44

Klanert, G., Jadhav, V., Chanoumidou, K., Grillari, J., Borth, N., Hackl M. (2014) Endogenous microRNA clusters outperform chimeric sequence clusters in Chinese Hamster Ovary cells. Biotechnol. J 9, 4, 538-544

Hackl, M., Jadhav, V., Klanert, G., Karbiener, M., Scheideler, M., Grillari, J., Borth, N. (2014) Analysis of microRNA transcription and post-transcriptional processing by Dicer in the context of CHO cell proliferation. J Biotechn. 190; 76-84

Harreither, E., Rydberg, H.A., Amand, H., Jadhav, V., Fliedl, L., Benda, C., Esteban, M.A., Pei, D., Borth, N., Grillari-Voglauer, R., Hommerding, O., Edenhofer, F., Norden, B., Grillari, J. (2014) Characterisation of a novel cell penetrating peptide derived from human Oct4. Cell Regeneration 3:2, DOI 10.1186/2045-9769-3-2

Maccani, A., Hackl, M., Leitner, C., Steinfellner, W., Graf, A.B., Tatto, N.E., Karbiener, M., Scheideler, M., Grillari, J., Mattanovich, D., Kunert, N., Borth, N., Grabherr, R., Ernst, W. (2014) Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation. Appl Microbiol Biotechnol in press

Ruth, C., Buchetics, M., Vidimce, V., Kotz, D., Naschberger, S., Mattanovich, D., Pichler, H., Gasser, B. (2014) Pichia pastoris Aft1 – a novel transcription factor, enhancing recombinant protein secretion Microbial Cell Factories, 13 (1), art. no. 120, .

Delic, M., Göngrich, R., Mattanovich, D., Gasser, B. (2014) Engineering of protein folding and secretion – Strategies to overcome bottlenecks for efficient production of recombinant proteins Antioxidants and Redox Signaling, 21 (3), pp. 414-437.

Mattanovich, D., Sauer, M., Gasser, B. (2014) Yeast biotechnology: Teaching the old dog new tricks Microbial Cell Factories, 13 (1), art. no. 34,

Maccani, A., Landes, N., Stadlmayr, G., Maresch, D., Leitner, C., Maurer, M., Gasser, B., Ernst, W., Kunert, R., Mattanovich, D. (2014) Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space-time yields for less complex proteins Biotechnology Journal, 9 (4), pp. 526-537.

Rebnegger, C., Graf, A.B., Valli, M., Steiger, M.G., Gasser, B., Maurer, M., Mattanovich, D. (2014) In Pichia pastoris, growth rate regulates protein synthesis and secretion, mating and stress response, Biotechnology Journal, 9 (4), pp. 511-525.

Nocon, J., Steiger, M.G., Pfeffer, M., Sohn, S.B., Kim, T.Y., Maurer, M., Rußmayer, H., Pflügl, S., Ask, M., Haberhauer-Troyer, C., Ortmayr, K., Hann, S., Koellensperger, G., Gasser, B., Lee, S.Y., Mattanovich, D. (2014) Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production, Metabolic Engineering, 24, pp. 129-138.

Traxlmayr, M.W., Lobner, E., Hasenhindl, C., Stadlmayr, G., Oostenbrink, C., Rüker, F., Obinger, C. (2014) Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution, Biotechnology Journal, 9 (8), pp. 1013-1022.

Woisetschläger, M., Antes, B., Borrowdale, R., Wiederkum, S., Kainer, M., Steinkellner, H., Wozniak-Knopp, G., Moulder, K., Rüker, F., Mudde, G.C. (2014) In vivo and in vitro activity of an immunoglobulin Fc fragment (Fcab) with engineered Her-2/neu binding sites, Biotechnology Journal, 9 (6), pp. 844-851.

Hasenhindl, C., Lai, B., Delgado, J., Traxlmayr, M.W., Stadlmayr, G., Rüker, F., Serrano, L., Oostenbrink, C., Obinger, C. (2014) Creating stable stem regions for loop elongation in Fcabs – Insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations, Biochimica et Biophysica Acta – Proteins and Proteomics, 1844 (9), pp. 1530-1540.

Rohringer, S., Holnthoner, W., Hackl, M., Weihs, A.M., Rünzler, D., Skalicky, S., Karbiener, M., Scheideler, M., Pröll, J., Gabriel, C., Schweighofer, B., Gröger, M., Spittler, A., Grillari, J., Redl, H. (2014) Molecular and cellular effects of in vitro shockwave treatment on lymphatic endothelial cells, PLoS ONE, 9 (12), art. no. e114806

Fliedl, L., Manhart, G., Kast, F., Katinger, H., Kunert, R., Grillari, J., Wieser, M., Grillari-Voglauer, R. (2014) Novel human renal proximal tubular cell line for the production of complex proteins, Journal of Biotechnology, 176 (1), pp. 29-39.

Karbiener, M., Pisani, D.F., Frontini, A., Oberreiter, L.M., Lang, E., Vegiopoulos, A., Mössenböck, K., Bernhardt, G.A., Mayr, T., Hildner, F., Grillari, J., Ailhaud, G., Herzig, S., Cinti, S., Amri, E.-Z., Scheideler, M. (2014) MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes Stem Cells, 32 (6), pp. 1578-1590.

Fliedl, L., Wieser, M., Manhart, G., Gerstl, M.P., Khan, A., Grillari, J., Grillari-Voglauer, R. (2014) Controversial role of gamma-glutamyl transferase activity in cisplatin nephrotoxicity, Altex, 31 (3), pp. 269-278. Waaijer, M.E.C., Wieser, M., Grillari-Voglauer, R., Van Heemst, D., Grillari, J., Maier, A.B. (2014) MicroRNA-663 induction upon oxidative stress in cultured human fibroblasts depends on the chronological age of the donor, Biogerontology, 15 (3), pp. 269-278.

Brugger, D., Krondorfer, I., Shelswell, C., Huber-Dittes, B., Haltrich, D., Peterbauer, C.K. (2014) Engineering pyranose 2-oxidase for modified oxygen reactivity, PLoS ONE, 9 (10), art. no. 0109242.

Arreola, S.L., Intanon, M., Suljic, J., Kittl, R., Pham, N.H., Kosma, P., Haltrich, D., Nguyen, T.-H. (2014) Two β-galactosidases from the human isolate Bifidobacterium breve DSM 20213: Molecular cloning and expression, biochemical characterization and synthesis of galacto-oligosaccharides, PLoS ONE, 9 (8), art. no. e104056

Paukner, R., Staudigl, P., Choosri, W., Sygmund, C., Halada, P., Haltrich, D., Leitner, C. (2014) Galactose oxidase from Fusarium oxysporum – Expression in E. coli and P. pastoris and biochemical characterization, PLoS ONE, 9 (6), art. no. e100116

Krondorfer, I., Lipp, K., Brugger, D., Staudigl, P., Sygmund, C., Haltrich, D., Peterbauer, C.K. (2014) Engineering of pyranose dehydrogenase for increased oxygen reactivity, PLoS ONE, 9 (3), art. no. e91145

Bort, J.A.H.; Shanmukam, V.; Pabst, M.; Windwarder, M.; Neumann, L.; Alchalabi, A.; Krebiehl, G.; Koellensperger, G.; Hann, S.; Sonntag, D.; Altmann, F.; Heel, C.; Borth, N. (2014) Reduced quenching and extraction time for mammalian cells using filtration and syringe extraction. J BIOTECHNOL. 2014; 182: 97-103

Chu, D.B.; Klavins, K.; Koellensperger, G.; Hann, S. (2014) Speciation analysis of sugar phosphates via anion exchange chromatography combined with inductively coupled plasma dynamic reaction cell mass spectrometry – optimization for the analysis of yeast cell extracts. J ANAL ATOM SPECTROM. 2014; 29(5): 915-925

Guerrasio, R.; Haberhauer-Troyer, C.; Mattanovich, D.; Koellensperger, G.; Hann, S. (2014) Metabolic profiling of amino acids in cellular samples via zwitterionic sub-2 ìm particle size HILIC-MS/MS and a uniformly 13C labeled internal standard. Anal Bioanal Chem. 2014; 406(3):915-922

Klavins, K.; Chu, D.B.; Hann, S.; Koellensperger, G. (2014) Fully automated on-line two-dimensional liquid chromatography in combination with ESI MS/MS detection for quantification of sugar phosphates in yeast cell extracts. ANALYST. 2014; 139(6): 1512-1520.

Klavins, K.; Drexler, H.; Hann, S.; Koellensperger, G. (2014) Quantitative Metabolite Profiling Utilizing Parallel Column Analysis for Simultaneous Reversed-Phase and Hydrophilic Interaction Liquid Chromatography Separations Combined with Tandem Mass Spectrometry. ANAL CHEM. 2014; 86(9): 4145-4150.

Nocon, J.; Steiger, M.G.; Pfeffer, M.; Sohn, S.B.; Kim, T.Y.; Maurer, M.; Russmayer, H.; Pflugl, S.; Ask, M.; Haberhauer-Troyer, C.; Ortmayr, K.; Hann, S.; Koellensperger, G.; Gasser, B.; Lee, S.Y.; Mattanovich, D. (2014) Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production. METAB ENG. 2014; 24: 129-138.

Ortmayr, K.; Nocon, J.; Gasser, B.; Mattanovich, D.; Hann, S.; Koellensperger, G. (2014) Sample preparation workflow for the liquid chromatography tandem mass spectrometry based analysis of nicotinamide adenine dinucleotide phosphate cofactors in yeast. J SEP SCI. 2014; 37(16): 2185-2191

Publications Extremophile Center

Ettenauer, J.D., Jurado, V., Pinar, G., Miller, AZ., Santner, M., Saiz-Jimenez, C., Sterflinger, K. (2014): Halophilic Microorganisms Are Responsible for the Rosy Discolouration of Saline Environments in Three Historical Buildings with Mural Paintings. PLOS ONE. 2014; 9(8)

Pinar, G., Krakov, L., Pangallo, D., Piombino-Mascali, D., Maixner, F., Zink, A., Sterflinger, K. (2014): Halophilic bacteria are colonizing the exhibition areas of the Capuchin Catacombs in Palermo, Italy. Extremophiles. 2014; 18(4):677-691

Sterflinger, K., Lopandic, K., Pandey, RV., Blasi, B., Kriegner, A. (2014): Nothing Special in the Specialist? Draft Genome Sequence of Cryomyces antarcticus, the Most Extremophilic Fungus from Antarctica. PLOS ONE. 2014; 9(10)

Zakharova, K., Marzban, G., de Vera, JP., Lorek, A., Sterflinger, K. (2014): Protein patterns of black fungi under simulated Mars-like conditions. SCI REP-UK. 2014; 4

Zakharova, K., Sterflinger, K., Razzazi-Fazeli, E., Noebauer, K., Marzban, G. (2014): Global proteomics of the extremophile black fungus Cryomyces antarcticus using 2-D electrophoresis. Natural Science, 6, 978-995; ISSN 2150-4091

Sterflinger, K., Tafer, H., Lopandic, K., Blasi, B., de Hoog, S. (2015) Draft genome of Cladophialophora immunda, a black yeast and efficient degrader of polyaromatic hydrocarbons. Genome Announcements, Jan 2015 (in press)

Blasi, B., Tafer, H., Tesei, D., Sterflinger, K. From glacier to sauna: RNA-seq of the human pathogen black fungus Exophiala dermatitidis under varying temperature conditions exhibits common and novel fungal response. PLOS ONE: minor revision

Pflügl, S., Marx, H., Mattanovich, D., Sauer, M. (2014) Heading for an economic industrial upgrading of crude glycerol from biodiesel production to 1,3-propanediol by Lactobacillus diolivorans. Bioresour Technol. 152:499-504.

Nocon, J., Steiger, M.G., Pfeffer, M., Sohn, S.B., Kim, T.Y., Maurer, M., Rußmayer, H., Pflügl, S., Ask, M., Haberhauer-Troyer, C., Ortmayr, K., Hann, S., Koellensperger, G., Gasser, B., Lee, S.Y., Mattanovich, D. (2014) Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production. Metab Eng. 24:129-38

Prielhofer, R., Cartwright, S.P., Graf, A.B., Valli, M., Bill, R.M., Mattanovich, D., Gasser, B. (2014) Pichia pastoris regulates its gene-specific response to different carbon sources at the transcriptional, rather than the translational, level. BMC Genomics. 2015 Dec;16(1):1393.

Bellasio, M., Mattanovich, D., Sauer, M., Marx, H. (2015) Organic acids from lignocellulose: Candida lignohabitans as a new microbial cell factory. J Ind Microbiol Biotechnol. In press

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